芳香酶抑制剂依西美坦(Exemestane)的合成

Synthesis of aromatase inhibitor exemestane

摘要: 目的:合成依西美坦并改进合成工艺。方法:以雄甾烯二酮为原料,经Mannich反应、溴化、脱溴等数步反应制得依西美坦。结果:所得产物经元素分析、紫外光谱、红外光谱、核磁共振谱及质谱等确证了结构。结论:此路线是可行的

Abstract: OBJECTIVE: To synthesize exemestane and optimize the process. METHOD: This compound was synthesized by steps of Mannich reaction, bromination, and debromination. RESULT: Chemical structure of the product was conformed by element analysis, UV, IR,1HNMR, an