因卡膦酸二钠的合成

Synthesis of Incadronate

摘要: 目的:合成因卡膦酸二钠,并进行工艺改进。方法:即以环庚胺、亚磷酸二乙酯、原甲酸三乙酸为起始原料,经二步反应合成因卡膦酸二钠。结果:避免了硅胶柱分离工艺,产物经IR、NMR、MS及元素分析、热分析确证了化学结构。结论:合成方法收率稳定,工艺简单

Abstract: OBJECTIVE: To synthesize Incadronate and optimize the process. METHOD: Taking cycloheptylamine,diethyl phosphite and triethyl orthoformate as the starting material,Incadronate was synthesized by two steps of reaction. RESULTS: Separation of silica gel col