对氟苄胺合成工艺的改进

Improvement of synthetic process of p-fluorobenzylamine

摘要: 目的:获得成本低、工艺简单的合成方法。方法:以对硝基苯甲酸为原料经氟化、酰化和还原3步合成药物中间体对氟苄胺。结果:总收率达3 0 .4 3 %。结论:新的合成方法具有原料易得、成本低廉、操作安全和工艺简单等特点

Abstract: OBJECTIVE:To simplify the method of synthesizing p-fluorobenzylamine and low the cost of raw material. METHOD:p-Fluorobenzylamine, which is the intermediate compound of some medicine, was synthesized by 3 steps with p-Nitrobenzoic acid as starting materia