氯屈膦酸二钠合成工艺改进

Improved synthesis of clodronate

摘要: 目的:对氯屈膦酸二钠的合成工艺进行了研究。方法:以二溴甲烷和亚膦酸三异丙酯为原料,经缩合、氯化、热裂解和成盐反应得到氯屈膦酸二钠。结果:合成产物的化学结构经元素分析、红外光谱、质谱和核磁共振谱确证,总收率为6 0 .3%。结论:此合成路线是完全可行的。

Abstract: OBJECTIVE:To study the synthesis of clodronate.METHODS:Clodronate was synthesized by steps of condensation,chloration,pyrolysis and salifying from dibromomethane and triisopropyl phosphite.RESULTS:The chemical structure of synthetic product was confirmed