美沙拉嗪缓释片的处方筛选及体外释放度研究

Prepaeration and release of sustained release mesalazine tablets

摘要: 目的:制备美沙拉嗪缓释片剂,并评价其体外释放特性。方法:用正交试验设计对片剂的处方进行筛选,制备美沙拉嗪缓释片剂,测定其释放特性。结果:以优选的处方所制备的片剂,体外释药性能符合Higuchi模型,持续释药达8h。结论:该片剂工艺简单,可适合工业化生产

Abstract: OBJECTIVE:To prepare sustained release tablets and evaluate its drug release property.METHOD:The formulation of the tablet was found by orthogonal design test.RESULTS:The release rate of the prepared tablets conformed to Higuchi equation and the drug was