抗溃疡药瑞巴匹特的合成

Synthesis of ribamipide an antiulcer agent

摘要: 目的:合成抗溃疡药2-( 4-氯苯甲酰胺基)-3-( 1 ,2-二氢2-氧代 4-喹啉基)丙酸(瑞巴匹特)。方法:以乙酰乙酰苯胺为起始原料,经溴化,成环,取代,酸解,及缩合等五步反应合成该化合物。结果:合成产物经元素分析,红外光谱,核磁共振谱,质谱等确证。结论:此合成路线是完全可行的。

Abstract: OBJECTIVE:To synthesize 2-(4-Chlorobenzoylamino)-3-(1,2-dihydro-2-oxo-4-quinolyl) propionic acid(ribamipide).METHOD:With acetoactanilide as the starting material,ribamipide was synthesized by bromination,cycloration,substitution,acidification,and condensa