异步六点法估算药物溶出度参数

Estimation of parameters of the medical dissolubility by asynchronous six-points method

摘要: 目的:在经典法与药典法基础上,提出了异步六点法。方法:采用异步六点法与经典法进行盐酸普奈洛尔片剂溶出度试验。结果:两者所得溶出度参数Td、T0.75基本一致。结论:试验表明本法可成倍减少工作量,省时实用。

Abstract: OBJECTIVE:This paper reported the asynchronous six points method on the base of the classical method and the pharmacopeia method.METHOD:The dissolubility for propranolol hydrochloride tablets was measured by the asynchronus six points method and classic