杂环类抗抑郁新药文拉法新(venlafaxine)的合成

Synthesis of novel heteracycl ic antidepressant venlafaxine

摘要: 目的:改进新型杂环类抗抑郁药文拉法新(venlafaxine)的合成方法。方法:该化合物以对羟基苯乙酸为原料,经醚华、酰氯华、酰胺化格氏反应、还原、成盐等步骤制备而成。结果:合成产物经元素分析、红外光谱、核磁共振谱、质谱和快原子轰击质谱等确证。结论:此合成路线是完全可行的

Abstract: OBJECTIVE:To modify the synthetic method of the novel heteracyclic antidepressant venlafaxine,1-(2-dimethylamino)-1-(4-methoxyphenyl)ethylcyclohexanol.METHOD:Venlafaxine was synthesized by steps of etherification,acid chloridization,amidation,Grignard r