一阶导数光谱法测定盐酸地尔硫缓释片的含量

Determination of diltiazem hydrochloride sustained release tablets by the first derivative spectrophotometry

摘要: 目的:建立测定盐酸地尔硫艹卓缓释片的含量测定方法。方法:以乙醇为溶剂,以一阶导数光谱的谷-零位值法测定盐酸地尔硫艹卓的含量,测定波长λ谷=2 50±1nm。结果:回收率100.01% ,RSD0.38%～0.47% ,线性范围2.4～16.8μg/ml。结论:方法简便、快速、准确,适合于该制剂的含量测定。

Abstract: OBJECTIVE:To establish an accurate method for the determination of diltiazem hydrochloride in its sustained release tablets.METHODS:A first derivative spectrophotometric method was used by valley-zero method for the determination of diltiazem hydrochlorid