灰黄霉素中灰黄霉酸杂质及色泽的考查

Examination of griseofulvin acid in of griseofulvin by thin layer chromatography

摘要: 目的:本文采用薄层色谱法考查了不同厂家灰黄霉素中灰黄霉酸杂质的存在.方法:以丙酮为溶媒,精制灰黄霉素,摸索分离条件,探讨杂质限度,考查产品色泽.结果:杂质均值为0.276%,RSD为0.168%.结论:对改进产品检验方法、提高产品质量具有一定的参考价值.

Abstract: OBJECTIVE: To examine griseofulvin acid in griseofulvin by TLC. METHODS: Using acetone as solution, purified griseofulvin, found out the conditions to separate griseofulvin acid from griseofulvin, search out the limit of its contents, inspect and compare