羧烷基化合成萘普生工艺改进

Improved synthesis of dl-naproxen by carboxylation-alkylation

摘要: 1-溴-2-甲氧基萘与0-对甲基苯磺酰乳酸乙酯(1)在无水氯化铝催化下经Fniedel-Crafts反应,还原脱溴直接合成dl-萘普生(3),以上反应均在“一锅”内完成,收率达95%(以1-溴-2-甲氧基萘计算)。

Abstract: dl-Naproxen was directly synthesized via reduction and hydrolysis of ethyl (5-bromo-6-methoxy-2-naphthyl )-a -methyl acetate (2), which was prepared by Friedel-Crafts reaction with 1-bromo-2methoxynaphthalene and ethyl 0-(p-methyl benzene sulfonyl) lactat