药物对清醒无拘束豚鼠气道反应性的影响

Effects of Drugs on Airway Responsiveness to Histamine Aerosol inUnrestrained Conscious Guinea Pigs

摘要: 在清醒无拘束豚鼠,观察药物对组胺气雾剂气道反应性的作用.证明速激肽拮抗剂CP-96345和SR-—48968、汉防己甲素降低组胺气道反应性的作用,并表明氨茶碱、沙丁胺醇、扑尔敏也能降低气道反应性,普萘洛尔则增高气道反应性,地塞米松对气道反应性影响不显著.

Abstract: We observed the effects of drugs on airway responsiveness to histamine aerosolwith a determining system in unrestrained conscious guinea pigs. It wag demonstrated that CP-96345 and SR-48968, the specific antagoists of tachykinin receptors and tetrandrine,