对映体选择性测定尿中N-甲基-1-(3,4-亚甲二氧苯基)-2-丙胺及其代谢物
Enantioselective Determination of N-methyl-(3,4-methylenedioxyphenyl)-2-propanamineand Its Motabolites in Rats Urine
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摘要: 建立了尿中N-甲基-(3,4-亚甲二氧苯基)-2-丙胺及其代谢物对映体浓度的分析方法。药物经手性衍生化后,于非手性GC固定相上分离。采用该法测定了大鼠屎中各对映体浓度,结果表明药物及其代谢物均呈立体选择性代谢.Abstract: It is prescribed that a method for analysis of the enantiomeric concentrations ofN-methyl-(3,4-methylenedioxyphenyl)-2-propanamine and its primary metabolites in rats urine,The diastereomers were resolyed on an achiral GC cohurm after chiral derivatizatio
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