吲哚美辛和乙胺嗪对缺氧大鼠肺血管阻力的影响

Effects of Indomethacin and Diethylcarbamazine on Pulmonary VascularResistance in Rats with Hypoxia

摘要: 在慢性和急性缺氧条件下,Hilltop(HT)大鼠肺血管阻力(PVR)升高程度显著比Wistar(WT)大鼠高。吲哚美辛可减少WT大鼠PG2产生,提高PVR;对HT大鼠则减少TXA2产生,降低PVR。乙胺嗪和U-60257B通过抑制5-脂加氧酶使白三烯(LTs)产生减少,在缓解两种大鼠的缺氧性PVR增高中起重要作用。

Abstract: The pulmonary vascular resistance (PVR) of Hilltop (HT) rats was higher thanthat of Wistar (WT) rats during chronic and acute hypoxia. Indomethacin enhanced PVR inWT rats by decreasing the release of TXA2. Diethylcarbamazine and U-60257B inhibited the5-li