山莨菪碱对红细胞膜流动性和膜内源荧光的影响
Effect of Anisodamine on the fluidity of erythroyte membrane and the intrinsic fluorescence of ghost
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摘要: 应用荧光探针DPH测定完整红细胞膜流动性。山茛菪碱显著增加红细胞膜流动性。山茛菪碱对红细胞膜内源荧光的焠灭呈药物浓度依赖,钙和山茛菪碱对红细胞膜内源荧光的焠灭有协同作用,提示山茛菪碱对膜疏水区有作用,并且直接与膜蛋白反应导致能量转移。Abstract: Anisodamine(Ani)could increase significantly the intact erythrocyte membrane fluidityin the presence or absence of CaCl2.The intrinsic fluorecence of erythrocyte ghost was depressedby Ani in a dose-dependent manner.In the presence of 2 mmol/L CaCl2 and An
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