诺氟沙星(Norfloxacin)合成工艺的改进

    Improvement of technological process for Synthesis of Norfloxacin

    • 摘要: 利用硼鳌合物的方法,增大6—氟与7—氯取代活性的差异,使哌嗪化选择性取代收率达到82.3%。

       

      Abstract: Norfloxacin was prepared according to the Boric coordination complex method with mod ification. An available process starting from ethyl-1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylate to Norfioxacin in 82.3% yield was described.

       

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