利福定固体分散物的制备及生物利用度测定

The Preparation and Determination of Bioavailability of Rifandin Solid Dispersion

摘要: 用溶媒法制备了利福定固体分散物。经X—射线衍射实验证明,利福定在固体分散物中呈无定形或以分子状态分散于载体中。固体分散物2小时的体外溶出量和人体生物利用度分别较原药提高了88%和21.8%。

Abstract: Rifandin Solid Dispersion (RSD) were prepared by using "solvent method". Result showed that Rifandin (R) was dispersed in carrier with amorphous or molecularity through x-ray diffract experiment. The disolution amount of R in RSD was 88% more than that of