3—4—2(羟基乙基)哌嗪基甲基—联苯对二酚对体外培养心肌细胞作用的研究

Effects of 3-4-2(hydroxyethyl) piperazinyl methyl-P-dihydoxydiphenyl on Cultured Heart Cells in vitro

摘要: 3—4—2(羟基乙基)哌嗪基甲基—联苯对二酚(N22)为苯酚的衍生物,属非甾体类抗炎药。本文研究了N22对体外培养心肌细胞的作用,结果表明N22对大鼠体外培养心肌细胞搏动有明显的负性频率作用,并伴有搏动强度减弱作用;对自发性或由乌豆碱诱发的速发型心律失常有明显的对抗作用。

Abstract: 3-4-2(hydroxyethyl) piperazinyl methyi-P-dlhydoxydiphenyl derived from phenol was a nonsteroidal antimflammatory drug possessing antimflammatory and antipyretic-analgesic activities. Effect of 3-4-2(hydroxyethyl)piperazingl methyl-P-dihydoxydiphenyl o