Abstract: OBJECTIVE To review the general situation of progress in natural products with anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. METHODS Consult the literatures at home and abroad. RESULTS Eighty five natural products including cyclic peptides, alkaloids, terpenoids, quinones, flavanones and macrolides were reported. Among them, fifty eight compounds were isolated from the metabolites of microorganisms, twenty six compounds from plants, and one compound from a sponge. There was one element of chlorine, or bromine and sulfur in the structures of eleven compounds. Thirty compounds showed anti-MRSA activities, and their minimum inhibitory concentrations were lower than 5 μg·mL^-1. CONCLUSION Based on many compounds with anti-MRSA activity isolated from the metabolites of microorganisms and plants, it is necessary to develop and research widely when the situation infected by drug-resistance pathogenic bacteria including MRSA is daily grimness.