Abstract: OBJECTIVE To study the effects of Qubaibabuqi on trace elements and immunoglobulin in serum of copper and zinc deficient rats. METHODS Preliminary studying on internal resorption of trace elements by establishing model of copper or zinc deficient rat in controling feeds, determinating the level of related immune globulin by nephelometry. RESULTS The animal model of Cu, Zn-lack was constructed successfully. After administration on the animal model, the Cu, Zn in the compound Qubaibabuqi had a different degree absorption, and it also had a certain effect on other trace element. Lower the level of Cu, Zn in rats could rise the levels of Fe, Mn, Se and decrease the levels of Mg, Sr in the serum, but it had no effect on Ca. Opposite to this, rising the levels of Cu, Zn could low the the level of Fe, Se and rise the level of Ca, Mg, Sr, but it had no effect on Mn. At the same time, the loss and supplement of Cu, Zn have different degree regulate on IgG, IgA, IgM in the serum of SD rats. CONCLUSION Cu, Zn in the compound recipe Qubaibabuqi can be absorbed by organism, and effect the absorption of other trace elements and macroelements. Meanwhile it has some influence on IgG, IgA, IgM of organism and supply evidence to its basic study.