加合钠离子的血管紧张素转换酶抑制剂类化合物的质谱分析

Analysis of Angiotensin-converting Enzyme Inhibitors by Mass Spectrometry

摘要: 目的建立在加合钠离子条件下血管紧张素转换酶抑制剂类化合物质谱鉴定和分析的新方法。方法电喷雾离子阱质谱，注射泵直接进样。结果在加合钠离子的条件下，都出现了特殊的重排离子，通过对碎裂离子的分析，总结了这类化合物在加合钠离子的条件下的质谱碎裂特征。结论采用解析加合钠离子的准分子离子碎裂途径的方法，有助于对这类化合物的结构推断。

Abstract: OBJECTIVE To establish a method for the identification of angiotensin-converting enzyme (ACE) inhibitors. METHODS Electrospray ionization tandem mass spectrometry (ESI-MS²) was employed and samples were introduced by a syringe pump. RESULTS Their fragmentation pathways were described and a unique rearrangement was observed for the eight compounds. CONCLUSION These characters can be used for future studies of ACE inhibitors.