Abstract: OBJECTIVE To assess the effect of dexmedetomidine on the intraoperative fentanyl requirements and perioperative hemodynamics in patients undergoing intracranial tumor surgery. METHODS Thirty patients scheduled for intracranial tumor surgery were recruited, randomized assigned into receive dexmedetomidine or placebo groups, D and P, respectively. In group D patients received a loading dose of dexmedetomidine 0.5 μg·kg^-1 over 20 minutes, followed by a continuous infusion of a rate of 0.9 μg·kg^-1·h^-1. In group P, patients received a volume matched 0.9% saline. Opioid requirement, heart rate (HR), blood pressure (BP) and end-tidal sevoflurane concentration were monitored. RESULTS The fentanyl consumption was 436.7, 663.3 μg in the D and P groups, respectivly (P<0.05 for comparison of the D and P group). From the anesthesia induction to 40 min after anesthesia induction, the D group had slower heart rate and lower mean arterial blood pressure .The end-tidal sevoflurane concentration was lower in the D group after 60 min of anesthesia induction. CONCLUSION Intraoperative dexmedetomidine infusion significantly decreases fentanyl and sevoflurane consumption, increases intraoperative haemodynamic stability during intracranial tumor surgery.