Abstract: OBJECTIVE To explore the analysis of olanzapine in the treatment of first-episode schizophrenic patients. To observe the electrocardiogram changes of the patients treated with olanzapine from different manufactories. METHODS Seventy patients with first-episode schizophrenia were randomly divided into homemade olanzapine group(35 cases) and imported olanzapine group (35 cases) who were treated for 8 weeks. Statistcs to the amount and information of electrocardiogram abnormality. RESULTS At the second week, there were significant difference in electrocardiogram abnormality between homemade olanzapine group and imported olanzapine group (P<0.05). Homemade olanzapine can cause more sinus tachycardia than imported olanzapine easily(P<0.05), no difference in the other electrocardiogram abnormality between two groups. CONCLUSION There are significant difference in electrocardiogram abnormality of the two drugs from different manufactories. We should pay more attention to it.