Abstract: OBJECTIVE To summary of progress in the study on physical stability and anti-aging of soild dispersion. METHODS The relevant articles in recent years were referred and summarized. RESULTS Thermodynamic and kinetic factors for the physical stability of solid dispersion were reviewed. Suggestions about the formulation design, preparation method and storage conditions to improve the physical stability of solid dispersion were also introduced. CONCLUSION The intensive study of physical stability mechanism of soild dispersion will promote the development of this technology in pharmaceutical research.