Abstract: OBJECTIVE To evaluate clinical effects and safety of interventional anti-tuberculosis chemotherapy gel assisted method in treatment of new smear-positive tuberculosis patients combined with endobronchial tuberculosis. METHODS A total of 115 patients who had been diagnosed with bronchoscope as endobronchial tuberculosis were randomly divided into two groups: interventional therapy group (n=70) and aerosolizing inhalation group (n=45). All patients were given anti-tuberculosis chemotherapy. After 2 and 6 months’ treatment, the clinical symptom improvement rate, the pulmonary tuberculosis lesion absorption rate, the sputum bacteria negative rate and bronchoscopic features’ transition were compared. RESULTS After 2 months’ treatment, the clinical symptom improvement rate, the pulmonary tuberculosis lesion absorption rate, the sputum bacteria negative rate, the bronchoscope features’ transition Ⅰ type rate and Ⅱtype rate of interventional therapy group and aerosolizing inhalation group were 92.9% and 77.8%, 91.4% and 53.3%, 95.7% and 75.6%, 96.4% and 64.7%, 96.2% and 56.3%, respectively. There was significant difference between two groups(P<0.05 or P<0.01). After 6 months, only the pulmonary tuberculosis lesion absorption rate improved noticeably. CONCLUSION Use of interventional anti-tuberculosis chemotherapy gel assisted method to treat new smear-positive tuberculosis patients combined with endobronchial tuberculosis can quickly relieve clinical symptom, accelerate the absorption of focus, raise clinical effects.