含 2-取代-1,3-二硫杂环戊烷席夫碱大环化合物的合成及其抑菌活性研究

Synthesis and Antibacterical Activity of Novel Macrocyclic Schiff Base Compounds Containing 2-Substituted-1,3-dithiolane

摘要: 目的开发新型抗菌药物。方法以不同的β-二酮、二硫化碳、1,2-二溴乙烷等为原料合成含2-取代-1,3-二硫杂环戊烷大环席夫碱化合物，并进行初步抑菌活性研究。结果合成得到的中间体(Ⅰa~Ⅰc)及目标席夫碱大环化合物(Ⅱa~Ⅱc)经元素分析、红外光谱、1H-NMR、MS等手段进行了结构表征。合成的席夫碱大环化合物抑菌能力优越。结论本试验合成了含2-取代-1,3-二硫杂环戊烷大环席夫碱化合物，其具有更加优越的抑菌能力。

Abstract: OBJECTIVE To exploit a novel antibacterical agent. METHODS A series of macrocyclic Schiff base compounds containing 2-substituted-1,3-dithiolane were synthesized from different β-diketonato, carbon disolfide and 1,2-dibromoethane. Their antibacterial activities were tested. RESULTS The structure and composition of the middle compounds(Ⅰa-Ⅰc) and title Schiff base compounds(Ⅱa-Ⅱc) were elucidated on the basis of elemental analysis, IR, 1H-NMR, and MS. The title Schiff base compounds proved a better antibacterial activity. CONCLUSION The title Schiff base compounds(Ⅱa-Ⅱc) are synthesized, and they show good antibacterial activity.