Abstract: OBJECTIVE To investigate the incidence of inpatient adverse drug reaction (ADR) in our hospital and improve rational clinical use of drugs. METHODS A total of 1 094 cases of inpatient ADR in our hospital during 2006 and 2008 were counted up, classified and analyzed. The differences of ADR incidence rate between different drugs and in different manufacturing locations were compared. RESULTS The highest incidence of ADRs occurred in drugs that affected the body's immune function(1.038%), drugs used in eldly patient(0.585%) and traditional Chinese medicine injections(0.512%), which showed significant differences with overall ADRs incidence. The ADR incidence of Chinese medicine was 0.175%, and the Western medicine was 0.498%. There were significant differences between the Western and Chinese medicine(P<0.01)，but no difference with the incidence of serious ADR(P>0.05). The Chinese-made drugs and import/joint drugs had no difference with the incidence of ADR or serious ADR(P>0.05). CONCLUSION In addition to emphasizing ADRs monitor and reports, comparative study methods should be paid more attention to and impersonal evaluation should be strengthened in order to improve rational clinical use of drugs.