车前草醇提液降大鼠血尿酸作用的研究

Hypouricuria Effects of Alcoholic Extract of Plantaginis Herba on Rats

摘要: 目的研究车前草醇提液的降血尿酸作用。方法将大鼠随机分成空白对照组、模型组、别嘌呤醇组(0.10 g·kg^-1·d^-1)、车前草醇提液高(生药8.00 g·kg^-1·d^-1)、中(生药2.67 g·kg^-1·d^-1)、低(生药0.89 g·kg^-1·d^-1)剂量组，采用皮下注射氧嗪酸和灌胃次黄嘌呤建立急性大鼠高尿酸血症模型；用HPLC测定大鼠血清中尿酸含量。结果与模型组相比，车前草醇提物高、中、低剂量可显著降低大鼠血尿酸水平(P<0.05)。结论车前草醇提物具有降血尿酸的作用。

Abstract: OBJECTIVE To observe the hypouricuria effect of alcoholic extract of Plantaginis Herba. METHODS Rats were divided into six groups randomly as follows: control group, model group, allopurinol group, alcoholic extract of Plantaginis Herba groups (high-dose group, mid-dose group, low-dose group). Rats model of hyperuricemia were established by the subcutaneous injection of oteracil potassium and intragastric administration of hypoxanthine. The level of serum acid was determined by HPLC. RESULTS Compared with model group, the high-dose, mid-dose and low-dose medication administration groups could decrease the serum uric acid levels of hyperuricemic rats significantly(P<0.05). CONCLUSION Plantaginis Herba suggests considerable hypouricuria effect.