Abstract: OBJECTIVE To introduce the newly application of poloxamers in enhancing dissolution and bioavailability properties of hydrophobic drugs. METHODS With reference to research literatures published home and abroad during the past two or three years, this paper summarizes many new dosage forms of hydrophobic drugs using poloxamer 407 and poloxamer 188 as polymeric carriers. RESULTS The new dosage forms, including in-situ forming gels, solid dispensions, nanoemulsions, nanoparticles and composite preparations, were characterized by many superior features like better compliance, higher dissolution and bioavailability of model drugs, as well as an obvious property of sustained release. CONCLUSION The two poloxamers had been proved to be one of the ideal carriers for hydrophobic drugs, and they do have a great potential in increasing solulability and creating new drug delivery systems for many water-insoluable traditional Chinese medicines.