Abstract: OBJECTIVE To extract four ingredients for medicine in Lonicera macranthoides Hand Mazz. and find an ingredient that has strong anti-atherosclerosis effect by cell and animal experiments. METHODS Rathonum red stain and high performance liquid phase analytic process were used to assess and detect the level of cholesterol. The shapes of aorta in apoE-deficent mice were examined and the changes of intimal and plaque were observed. RESULTS All of the four ingredients in Lonicera macranthoides Hand Mazz. can reduce cholesterol of dutch fat cells. CONCLUSION Flavonoids in Lonicera macranthoides Hand Mazz. have strong anti-atherosclerosis effect.