Abstract: OBJECTIVE To prepare the effervescent tablets of famotidine and establish its quality standards. METHODS The formulation was optimized by single factor screening experiments. Famotidine effervescent tablets were prepared using direct compression method, with poloxamer 188 as material carriers of solid dispersion of famotidine. Then the character, weight difference, disintegration time, acidity and the content were tested. RESULTS The optimal formulation was as follows: tartaric acid-sodium bicarbonate=1∶1, the percentage of disintegrant, PEG6000 and magnesium stearate was 60%, 3%, 0.3%, respectively. The tablets disintegrated entirely in 5 minutes. CONCLUSION The optimal formulation is feasible, the preparation techniques is simple, and can be widely used.