Abstract: OBJECTIVE To investigate the correlations of serum sodium valproate concentration in epileptic children with clinical therapeutic effect, dosage, dosage form, sex, age and body weight. METHODS Our clinical pharmacy room’s 337 cases monitoring records of serum sodium valproate concentration in children with epilepsy were researched retrospectively and data as concentrations, sex, age etc were put into data base, which were analyzed and treated by SPSS 13.0 software. RESULTS No significant correlation was noted between serum sodium valproate concentration in epileptic children and sex, however it was closely correlated with therapeutic effect, dosage, dosage form, age and body weight. CONCLUSION The individual difference in the metabolic processes of sodium valproate within individual patient was obvious, so it’s necessary to make individualized remedy according to patients’ specific condition and monitoring result.