Abstract: OBJECTIVE To select a reasonable dry method for extracting dry powdered Qinxiangzhixie, meanwhile to provide basis for future research, we compared the influence of spray drying and decompression drying on hydroscopicity and fluidity of dry powdered extract of Qinxiangzhixie. METHODS The moisture absorption speed of dry powder extract of Qinxiangzhixie was determined. Its dynamics model was established, when the relative humidity (RH) of moisture absorption reached 2%. The parameter of moisture absorption speed was collected and compared. Its fluidity was contrasted through inspecting the angle of repose dry powdered Qinxiangzhixie. RESULTS Both of the dry methods dynamics model were conformed to log-normal model. However, the moisture absorption speed of decompression drying was quicker than spray drying. The research also demonstrated that the function of moisture absorption capacity-RH conformed to Logistic model, and the dry powder extract of decompression drying conformed to amended exponential function curve. When the moisture absorption amounts 2%, the relative humidity of the dry powdered extract of spray drying was 90.12%, and the dry powdered extract of decompression drying was 85.81%. That means the angle of repose of the dry powder extract of decompression drying was larger than spray drying and the fluidity of the dry powder extract of decompression drying was poorer than spray drying. CONCLUSION The dry powder extract by spray drying is less absorption, more stable and fluid.