Abstract: OBJECTIVE To study the protective effect of meloxicam on brain damage of Alzheimer’s disease(AD) model rats. METHODS The AD model rats were established via intragastric administration of aluminum gluconate (element aluminum 200 mg·kg^-1) once a day, 5 d a week for 20 weeks. Given 3 mg meloxicam per kg rat body weight and 1 mg meloxicam per kg rat after gavage given aluminum. After the success of modeling, pathomorphological changes of hippocampal neuron and the spatial learning and memory ability of rats were determined. The SOD, MAO-B activities, and the MDA contents of brain tissue in rats were measured. RESULTS The AD model rats’ spatial learning and memory ability was significantly decreased and hippocampal neuronal injury in rats. In the rat brain tissue, the MAO-B activities and the MDA content was significantly increased, at the same time, the SOD activities of rat brain tissue was significantly decreased. Meloxicam could provide significantly improvement in learning and memory function and hippocampal neuronal death of AD model rats, and could significantly reduced MDA contents in AD model rats’ brain tissue. Simultaneously, meloxicam could increase the SOD activities and decreased the MAO-B activities of AD model rats. CONCLUSION Meloxicam could noticeable prove the learning and memory function of AD rats, meloxicam has marked protective effect on AD model rats.