Abstract:
Traditional pharmacological treatments for attention deficit hyperactivity disorder(ADHD) are limited by high incidence of adverse reactions, suboptimal adherence, and modest social acceptance. As software-driven therapeutic interventions, digital drugs(DD) offer safe, scalable, and personalized options for children with ADHD. This review focuses on DD in ADHD management: first, it explores potential neural mechanisms underlying their effects; second, it systematically summarizes major technological approaches—including gamified cognitive training, behavioral monitoring and feedback systems, immersive interaction technologies, and AI-driven personalized interventions—together with supporting clinical evidence; finally, it objectively compares DD with conventional medications in terms of efficacy, safety, and cost-effectiveness, and discusses current challenges and future directions, aiming to provide insights for building integrated treatment frameworks that combine pharmacotherapy with DD.