国际视阈下药品说明书适老化研究热点与启示

赫玉芳; 吕侃; 武新亮; 王鑫禹; 赵乾; 夏昉

doi:10.13748/j.cnki.issn1007-7693.20250516

国际视阈下药品说明书适老化研究热点与启示

Hot Spots and Implications of Ageing Research on Drug Package Inserts in International Perspective

摘要

摘要:
目的探讨国际视阈下药品说明书适老化研究热点，为中国药品说明书适老化改革提供实践参考。
方法检索PubMed、Scopus和Web of Science(WOS)核心数据库2000—2024年相关学术文献，通过隐含狄利克雷分布(Latent Dirichlet Allocation，LDA)主题建模，测算主题强度，识别热点主题。
结果 “用药信息传递”“用药安全警示”“不良反应监测”“可读性及评估”被识别为当前的研究热点，系统揭示了老年患者在药品说明书信息获取、理解与使用中的关键问题，并为中国药品说明书适老化改革提供了理论支持和实践方向。
结论中国药品说明书未来的优化方向可以多模态信息获取、个体化风险管理、不良反应监测与可读性标准评估为核心，推动药品说明书向更加智能化、人性化、精准化的方向发展。

Abstract:
OBJECTIVE To explore the research hotspots related to the ageing-friendliness of drug package inserts from an international perspective and to provide practical references for reforming drug package inserts for the elderly in China.
METHODS A comprehensive literature search was conducted in the PubMed, Scopus and Web of Science Core Collection databases for academic publications from 2000 to 2024. Latent Dirichlet Allocation(LDA) topic modeling had been a process by which the intensity of topics was measured and hot topics were identified.
RESULTS The primary research hotspots were categorized into 4 themes: medication information communication, medication safety warnings, adverse reaction monitoring and readability and evaluation. These themes systematically reflect the major barriers faced by elderly patients in acquiring, understanding and utilizing pharmaceutical information. The findings will offer theoretical guidance and practical directions for enhancing the accessibility and usability of drug package inserts.
CONCLUSION The future optimisation direction of drug instructions in China could thus be centred on multimodal information acquisition, individualised risk management, adverse reaction monitoring, and assessment of readability criteria. The promotion of such measures will ensure the development of drug package inserts in the direction of greater intelligence, humanisation and precision.

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