国家集中带量采购药品头孢呋辛钠疗效与安全性的真实世界研究

孙静雯; 蔡鸿福; 林碧娟; 刘茂柏; 曾晓芳

doi:10.13748/j.cnki.issn1007-7693.20243281

国家集中带量采购药品头孢呋辛钠疗效与安全性的真实世界研究

Real-world Study on the Efficacy and Safety of Cefuroxime Sodium: A Drug Procured Through National Centralized Volume-based Procurement

摘要

摘要:
目的通过比较国家集中采购药品和原研药品注射用头孢呋辛钠在围手术期预防用药的有效性、安全性，找出更安全、有效、经济的预防用药方案，为围手术期预防用药提供依据。
方法抽取福建医科大学附属协和医院围手术期使用注射用头孢呋辛钠预防感染的手术患者电子病历数据，使用SPSS 27.0软件进行倾向性评分匹配后，分析2组药品预防术后感染的有效性、安全性、经济性指标。
结果集采组和原研组头孢呋辛钠的有效性、不良反应发生率均差异均无统计学意义。2组患者经济性指标差异有统计学意义(P<0.05)，相较于原研组，集采组费用显著减少。
结论在围手术期预防应用注射用头孢呋辛钠的患者中，集采和原研药物预防术后感染的有效性及安全性相当。而在预防术后感染方面，相对于原研药物，集采药物经济性更高。

Abstract:
OBJECTIVE To compare the efficacy and safety of nationally centralized procurement drugs and original research drugs of cefuroxime sodium for injection in perioperative prophylactic use, identify a safer, more effective and economical prophylactic medication scheme, and provide a basis for perioperative prophylactic medication.
METHODS Electronic medical record data of surgical patients receiving cefuroxime sodium for prophylactic infection were extracted from Fujian Medical University Union Hospital. After applying propensity score matching through SPSS 27.0, the study analyzed the effectiveness, safety, and economic indicators of the two drug groups in preventing postoperative infections.
RESULTS Upon comparing the prophylactic efficacy and the incidence of adverse reactions of cefuroxime sodium from the centralized procurement group versus the original research drug, no statistically significant difference was observed. However, there was a statistically significant difference in the economic indicators between the two groups(P<0.05). The centralized procurement group incurred significantly lower costs compared to the original research drug.
CONCLUSION There is no statistically significant difference in the effectiveness and safety of centralized procurement and original research drug in preventing postoperative infections in patients undergoing perioperative prophylaxis with cefuroxime sodium. Meanwhile, in preventing postoperative infection, compared to original drug, the cost of centralized procurement of drugs is more economical.

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