Abstract: Flavonoids are widely found in nature and are important natural organic compounds with various biological activities. In recent years, more and more reports have shown that viruses are a serious threaten to human health. The safe and effective antiviral activity of flavonoids has attracted widespread attention. Based on the classification of flavonoids, this article reviews their activities against various viruses, to provide a reference for the rational application of flavonoids in the development of antiviral drugs.