Abstract: Cannabidiol(CBD) is a non-psychoactive ingredient extracted from Moraceae plant Cannabis sativa L. It has the pharmacological effect of anti-fibrosis and is well tolerated and safe. This article primarily reviews the mechanisms of CBD's anti-fibrotic effects, which encompass modulating the endocannabinoid system, activating TRPV1 channels, and blocking GPR55 receptors, as well as regulating the expression of cytokines and growth factors. Additionally, CBD can alleviate inflammatory responses, activate PPAR-γ receptors, reduce oxidative stress, influence cellular apoptosis and autophagy processes, and accomplish these functions through modulating immune mechanisms. Significant effects of CBD have been observed in the treatment of fibrosis in organs such as the liver, lungs, heart, and kidneys. An analysis of its clinical applications is also presented, with the hope of providing valuable insights for further research in this field.