OBJECTIVE  To research each link of the the innovation chain, industrial chain, capital chain, and talent chain (hereinafter referred to as the "four chains"), accurately aligns key elements such as government, industry, academia, research, finance, services, and application, and construct an integration mechanism model to conduct an in-depth analysis of the development status of the "four chains" integration.

METHODS  By using the integration mechanism model, the study measured the development level of the "four chains" and the coupling coordination level of the "four chains" in the biopharmaceutical industry of the Yangtze River Delta region from 2018 to 2022, and analyzed the development weaknesses of the "four chains" integration in the biopharmaceutical industry of the Yangtze River Delta.

RESULTS  The overall development level of the "four chains" integration in the biopharmaceutical industry of the Yangtze River Delta showed an upward trend, progressing from mild disintegration to good integration; at the chain level, there was a significant differences in the development levels of the "four chains", with volatility present. The development weaknesses of the "four chains" integration in the biopharmaceutical industry of the Yangtze River Delta had shifted from the talent chain and capital chain to the innovation chain.

CONCLUSION  Based on the development levels of each link of the "four chains" and the weaknesses of the "four chains" integration, it is suggested that the Yangtze River Delta enhance the integrated development level and high-quality development of its biopharmaceutical industry by building medical innovation centers and technology transfer centers, implementing the revitalization of the traditional Chinese medicine industry, improving the financial system, and constructing digital logistics hubs.