基于响应面法结合熵权法优化浙贝母(灰贝)加工工艺

李莉; 杨先启; 陈军; 张叶峰; 邵将炜

doi:10.13748/j.cnki.issn1007-7693.20241360

基于响应面法结合熵权法优化浙贝母(灰贝)加工工艺

Optimization of Fritillariae Thunbergii Bulbus(Huibei) Processing Technology Based on Response Surface Method Combined with Entropy Weight Method

摘要

摘要:
目的应用响应面法结合熵权法优化浙贝母(灰贝)的加工工艺。
方法以伊贝辛、贝母辛、贝母素甲、贝母素乙、异贝母甲素为考察指标，熵权法确定各指标成分权重，在单因素试验的基础上，采用Box-Behnken响应面法设计优化浙贝母(灰贝)的加工工艺。
结果得到最优提取工艺为撞皮时间95 s、料灰比0.9%、发汗时间5 h、干燥温度45 ℃，验证结果与预测值偏差为0.5%。
结论响应面法优选的加工工艺稳定性好，可操作性强，可为浙贝母(灰贝)产地加工炮制一体化的质量控制提供科学依据。

Abstract:
OBJECTIVE To optimize the processing technology of Fritillariae Thunbergii Bulbus(Huibei) by response surface methodology combined with entropy weight method.
METHODS The single factor experiment combined with Box-Behnken design was used to optimize the processing technology, with 5 kinds of alkaloid(yibeissine, peimisine, peimine, peiminine, isobeta metrin) as the inspection indicators, combined with the weight coefficients were calculated by entropy weight method.
RESULTS The optimum extraction process was determined as follows: crashing time for 95 seconds, material-to-ash ratio for 0.9%, sweating time for 5 h, and drying temperature for 45 ℃. The RSD between the validation results and the predicted values was 0.5%.
CONCLUSION This optimized processing technology is stable amd feasible, which can provide the scientific basis for quality control of Fritillariae Thunbergii Bulbus(Huibei) processing technology.

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