Abstract: Diffusion cell test is one of the most commonly used in vitro model to detect the percutaneous absorption of cosmetic ingredients. Although PRC State Administration of Quality Supervision and Quarantine has issued the guideline for the in vitro test method for the percutaneous absorption of drug molecules, there is still a lack of guideline for the percutaneous absorption test of cosmetic components. In order to improve the standardized level and make the in vitro percutaneous absorption test of cosmetic ingredients more comparable, based on the international and domestic experience, Transdermal Drug Delivery Committee of the World Federation of Chinese Medicine Societies organized the experts to discuss and formed this consensus as reference for the percutaneous absorption test of cosmetic components.