OBJECTIVE To explore the therapeutic effect of 10 batches of volatile oil from different sources of Cinnamomum migao H. W. Li on rats with myocardial injury, and to analyze the therapeutic activity of volatile oil from different sources of Cinnamomum migao H. W. Li on rats with myocardial injury in combination with entropy weight method.

METHODS A rat model of myocardial injury was established. Western blotting was used to detect the levels of Bax/Bcl-2 proteins in myocardial tissue. Real-time quantitative PCR(RT-qPCR) was employed to measure the levels of fibroblast growth factor 2(FGF-2) in myocardial tissue. Immunohistochemistry(IHC) was used to analyze the expression of plasminogen activator inhibitor 1(PAI-1) and tissue plasminogen activator(TPA) in myocardial and aortic tissues of rats with myocardial injury treated with volatile oils from 10 batches of different sources of Cinnamomum migao H. W. Li. Hematoxylin-eosin(HE) staining was performed to assess the pathological changes in myocardial tissue. The entropy weight method was used to comprehensively evaluate the therapeutic effects of the 10 batches of volatile oils from different sources on myocardial injury in rats.

RESULTS The volatile oils from 10 batches of Cinnamomum migao H. W. Li from different sources could reduce the Bax/Bcl-2 levels in myocardial tissue, increase the FGF-2 levels, reduce the PAI-1 levels in myocardial and aortic tissues, and increase the TPA levels, and alleviating lesions in myocardial tissue. The results of the entropy weight method showed that the weight of TPA in myocardial tissue was the highest, the comprehensive scores for the volatile oils from Cinnamomum migao H. W. Li from Shuangjiang Town, Luodian County, Guizhou Province(October 2019) and Linmu Village, Ceheng County, Guizhou Province(October 2019) were the highest, while the scores for the volatile oils from Luokun Town, Luodian County, Guizhou Province(September 2018) and Luokun Town, Luodian County, Guizhou Province(October 2018) were the lowest.

CONCLUSION  The volatile oils from 10 batches of Cinnamomum migao H. W. Li from different sources may exert therapeutic effects on myocardial injury in rats by regulating the expression of Bax/Bcl-2 proteins, increasing FGF-2 levels, and enhancing the fibrinolytic system’s ability to prevent the deposition of fibrin in blood vessels and thrombus formation. There are certain differences in the therapeutic capabilities of the volatile oils from different sources, with the oils from Shuangjiang Town, Luodian County, Guizhou Province(October 2019) and Linmu Village, Ceheng County, Guizhou Province(October 2019) showing relatively better therapeutic effects, while those from Luokun Town, Luodian County, Guizhou Province(September 2018) and Luokun Town, Luodian County, Guizhou Province(October 2018) showing relatively poorer effects, this can provide a reference for the subsequent development of Cinnamomum migao H. W. Li volatile oils for the treatment of myocardial injury.