Abstract: Intervertebral disc degeneration(IVDD), as the basis of related spinal diseases, gradually shows a trend of younger age, so active and effective prevention and treatment will be the focus of its research. In recent years, with the continuous deepening of cell research, cell pyroptosis can affect the occurrence of IVDD by participating in intervertebral disc inflammation, the balance of cartilage metabolism and the degradation of extracellular matrix, and inhibiting intervertebral disc cell pyroptosis will effectively prevent the occurrence of IVDD. As a unique treatment method in China, traditional Chinese medicine has definite curative effect and obvious advantages in the field of IVDD. It can achieve the therapeutic effect of alleviating inflammatory response, maintaining bone metabolic balance and inhibiting the degradation of extracellular matrix by inhibiting pyroptosis.Therefore, this article aims to elucidate the relationship between cell pyroptosis and the occurrence and development of IVDD, and summarize the latest research progress on the intervention of traditional Chinese medicine monomers, extracts, and compound formulas in the treatment of cell pyroptosis for IVDD, providing new ideas for the pathogenesis and drugs, and providing theoretical basis for the clinical application of traditional Chinese medicine in the prevention and treatment of IVDD.