OBJECTIVE  To optimize the molding process of Quyu Jiedu Scrapping Ointment.

METHODS  Total scores of characteristics, high temperature stability, low temperature stability, centrifugal stability, and ductility were used as evaluation indicators. The prescription matrix ratio were screened by Box-Behnken response surface method. The cumulative osmotic amount and infiltration dynamic parameters of the paeoniflorin was used as the evaluation index to determine the type and content of the permeable penetration agent through the in vitro permeation test.

RESULTS  The best molding process of the Quyu Jiedu Scrapping Ointment was determined as follows: 45.8 g extract, 0.3 g Tween 80, 12.2 g glycerin monostearate, 5 g beeswax, 9 g lanolin, 9 g white vaseline, 26 g light liquid paraffin, 2.7 g emulsifier 80, 5.5 g azone and 0.2 g sorbic acid.

CONCLUSION  The moulding process of the Quyu Jiedu Scrapping Ointment is reasonable and feasible, and the quality is stable and controllable.