OBJECTIVE To review the plant sourses and the experimental research on diabetes of scopoletin with the aim of provide objective and comprehensive reference for scopolamine anti-diabetes research and new drug development.

METHODS A large number of relevant literatures at home and abroad were consulted, classified and analyzed, and summarized and summarized.

RESULTS Scopoletin was a natural compound, which could be extracted from a variety of medicinal plants and had many targets and low toxicity. In the treatment of diabetes, it had the effects of reducing hyperglycemia, promoting insulin secretion, improving insulin resistance, resisting oxidative stress injury and anti-inflammation. It also had therapeutic effects on diabetic complications such as diabetes-related eye diseases, diabetic nephropathy and diabetes-related bone diseases. The low oral bioavailability and obvious first-pass effect of scopoletin were the main obstacles to its development into a standardized drug.

CONCLUSION Scopoletin has great potential in anti-diabetes, but it still faces the problems of lack of high-quality clinical trials and the failure to develop standardized drugs. Its mechanism of action still needs systematic and standardized research. The development of product formulations with higher oral availability is the key to its subsequent clinical application. Scopoletin anti-diabetes has certain scientific and good application prospects, but there is still a long way to go from basic research to practical application.