Abstract:
OBJECTIVE To explore the correlation between the serum concentration of lamotrigine and UDPglucuronosyltransferase 2 family polypeptide B7(UGT2B7)-161C>T genetic polymorphism in pediatric patient with bipolar disorder in Xinjiang.
METHODS Blood samples of 82 pediatric patient treated with lamotrigine for bipolar disorder for at least 21 d were collected, and the plasma concentration of lamotrigine was determined by ultra-performance liquid chromatography. The first-generation sequencing method was used to detect the UGT2B7-161C>T genotypes, and the correlation between the polymorphisms of UGT2B7-161C>T genes and the plasma concentration of lamotrigine was analyzed.
RESULTS The concentration-to-dose ratio(CDR) values of the 41 pediatric patient who took lamotrigine as monotherapy and the other 41 pediatric patient who took other bipolar disorder drugs at the same time were significantly higher than those in the quetiapine fumarate group and fluoxetine group(P<0.05). There were significant differences in plasma drug concentration and CDR of lamotrigine of the different genotypes of UGT2B7-161C>T(P<0.05). Among them, the plasma concentrations and CDR results of UGT2B7 -161C>T CT and TT genotypes were significantly lower than those of CC genotypes(P<0.05).
CONCLUSION Mutations in the UGT2B7-161C>T genes affect serum levels of lamotrigine, and it is recommended to test the genetic phenotype of UGT2B7-161C>T when prescribing lamotrigine in patients with bipolar disorder.
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