Abstract: Depression is a mental illness characterized by a persistent low mood, and its pathogenesis is complex. The etiology of these disorders remains unclear, and there are still no effective targeted treatment regimens, posing a significant challenge in the field of medicine. Ferroptosis is a novel iron-dependent cell death mechanism implicated in the pathogenesis of various diseases, including neurological disorders, cancer, et al. However, its role in depression remains unclear. This paper examines the inherent relationships between ferroptosis and depression, focusing on key aspects such as lipid peroxidation, iron metabolism, and mitochondrial dysfunction. The objective is to explore novel therapeutic strategies for the treatment of depression based on the mechanisms of ferroptosis, ultimately offering a new perspective for the future treatment of this depression.