Abstract: Intranasal drug administration can avoid the blood-brain barrier, gastrointestinal degradation and liver first-pass effect, and may directly deliver drugs to the brain through the olfactory nerve pathway, so it is being used for the treatment of various neurological diseases. This article reviewed the research progress of intranasal drug delivery in terms of nasal anatomy, transport pathways of intranasal drug delivery for central nervous system diseases, mechanisms of action, clinical application, challenges and novel technologies.