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    替格瑞洛药物利用评价标准的构建和应用

    Establishment and Application of Drug Use Evaluation Standard of Ticagrelor

      摘要
    • 摘要:
      目的 建立替格瑞洛药物利用评价(drug use evaluation，DUE)标准，为临床合理应用替格瑞洛提供参考。
      方法 以替格瑞洛说明书为基础，参考相关指南、专家共识和文献，并通过专家咨询法，从用药指征、用药过程和用药结果3个方面建立替格瑞洛的DUE标准。采用回顾性研究法，对福建中医药大学附属第二人民医院2021年1—12月使用替格瑞洛的病历进行合理用药评价。
      结果 建立的替格瑞洛DUE标准分为三级，包括一级指标3项，二级指标14项，三级指标60项。共纳入使用替格瑞洛的病例263例，其中不合理率为72.62%，不合理情况主要为超适应证用药(60.08%)、药物转换(14.83%)和用法用量(5.70%)等方面。
      结论 建立的替格瑞洛DUE标准有较强的科学性、实用性和可行性，可为临床合理用药和处方点评提供参考依据。

       

      Abstract:
      OBJECTIVE To establish the drug use evaluation(DUE) standard of ticagrelor, and to provide a reference for the rational clinical application of ticagrelor.
      METHODS Based on the ticagrelor drug label, related guidelines and literature, combined with clinical expert consultation results, DUE standard from three levels (indications, medications and medication results) was established. A retrospective survey was conducted to evaluate the inpatients using ticagrelor from January 2021 to December 2021 in the Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine.
      RESULTS The DUE of ticagrelor was divided into three levels, including 3 first-level indexes, 14 second-level indexes and 60 third-level indexes. A total of 263 cases of using ticagrelor were included, of which the irrational rate was 72.62%. The irrational cases were mainly off-label use (60.08%), inappropriate drug conversion(14.83%) and unreasonable usage and dosage(5.70%), etc.
      CONCLUSION The established DUE standard of ticagrelor is scientific, practical and feasible, which can provide reference for clinical rational drug use and prescription evaluation.

       

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